Function of opossum lower esophageal sphincter during acute hypoxemia
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چکیده
منابع مشابه
Generation of Nitric Oxide in the Opossum Lower Esophageal Sphincter during Physiological Experimentation
Lipopolysaccharide (LPS), given in vivo, modulates opossum esophageal motor functions by inducing the inducible nitric oxide synthase (iNOS), which increases nitric oxide (NO) production. Superoxide, a NO scavenger, is generated during this endotoxemia. Superoxide is cleared by superoxide dismutase (SOD) and catalase (CAT) to protect the physiological function of NO. This study examined whether...
متن کاملUpper esophageal sphincter during transient lower esophageal sphincter relaxation: effects of reflux content and posture.
Although some studies show that the upper esophageal sphincter (UES) contracts during transient lower esophageal sphincter relaxation (TLESR), others show that it relaxes. We hypothesized that the posture of the subject and constituents of gastroesophageal reflux (GER) may determine the type of UES response during the TLESR. High-resolution manometry and esophageal pH/impedance recording were p...
متن کاملBiphasic relaxation of the opossum lower esophageal sphincter: roles of NO ⋅, VIP, and CGRP.
Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO ⋅) are thought to mediate lower esophageal sphincter (LES) relaxation. Transverse muscle strips from the opossum LES were used to test this hypothesis. Electrical field stimulation (EFS) produced a biphasic LES relaxation: a rapid component during the stimulus was more prominent at lower stimulus frequencies, and a sustained component...
متن کاملOpposing roles of K(+) and Cl(-) channels in maintenance of opossum lower esophageal sphincter tone.
The ionic basis underlying the maintenance of myogenic tone of lower esophageal sphincter circular muscle (LES) was investigated in opossum with the use of standard isometric tension and conventional intracellular microelectrode recordings in vitro. In tension recording studies, nifedipine (1 microM) reduced basal tone to 27.7 +/- 3.8% of control. The K(+) channel blockers tetraethylammonium (T...
متن کاملBiphasic relaxation of the opossum lower esophageal sphincter: roles of NO z, VIP, and CGRP
Uc, Aliye, S. T. Oh, Joseph A. Murray, Eugene Clark, and Jeffrey L. Conklin. Biphasic relaxation of the opossum lower esophageal sphincter: roles of NO z, VIP, and CGRP. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G548–G554, 1999.—Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO z) are thought to mediate lower esophageal sphincter (LES) relaxation. Transverse muscle strip...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93355-3